A recent study of over 1,000 adults indicated that the use of cannabis may lead to changes in the human body’s epigenome. The epigenome is responsible for regulating the activation or deactivation of genes, thereby influencing how our bodies function. The research, led by epidemiologist Lifang Hou from Northwestern University, sheds light on the potential effects of cannabis on our health and well-being. Despite the widespread use of cannabis in the United States, with 49 percent of individuals trying it at least once, there is still much unknown about its impact on the human body.
Research Methodology
Hou and her team examined data from a long-term study involving around 1,000 adults who were questioned about their cannabis use over a 20-year period. Blood samples were collected from the participants at two time points – 15 and 20 years into the study. The researchers focused on analyzing DNA methylation levels, a key epigenetic modification, to understand the potential impact of recent and long-term cannabis use on the participants’ epigenome.
The study revealed several interesting findings related to cannabis use and epigenetic markers. In the blood samples obtained at the 15-year mark, researchers identified 22 DNA methylation markers associated with recent cannabis use and 31 markers associated with cumulative cannabis use. Similarly, in the samples collected at the 20-year point, 132 markers were linked to recent use and 16 to cumulative use. Notably, one marker previously associated with tobacco use was also consistently identified, suggesting a potential shared epigenetic regulation between tobacco and cannabis usage.
The epigenetic changes observed in individuals who used cannabis were linked to various health outcomes, including cellular proliferation, hormone signaling, infections, neurological disorders like schizophrenia and bipolar disorder, and substance use disorders. However, it is essential to note that this study does not establish a direct causation between cannabis use and these epigenetic changes or health issues. Epidemiologist Drew Nannini from Northwestern University emphasized the need for further research to confirm these associations across diverse populations.
The study on cannabis use and epigenetic factors provides valuable insights into the potential consequences of cannabis consumption on the human body. By uncovering the intricate relationship between cannabis use and DNA methylation patterns, researchers aim to advance our understanding of the broader health implications associated with cannabis use. Moving forward, additional studies are warranted to validate and expand upon these initial findings, paving the way for a more comprehensive exploration of the impact of cannabis on our epigenome and overall health.
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